Amberen Menopause Relief Ingredients
What makes Amberen® unique is the use of scientifically researched ingredients to directly target the root cause of hormonal imbalance in a safe and effective way. In two double-blind clinical studies, Amberen® showed statistically significant improvements in relieving common menopausal symptoms.
The combination of Amberen’s unique ingredients with its patented manufacturing technology is the key to stimulate production of hormones naturally. High potency and bioavailability of our ingredients means that only very small amounts are needed to achieve desired results. This allows us to deliver powerful benefits in miniature, easy-to-swallow capsules.
The succinate anion is derived from Ammonium Succinate and, in this form, penetrates any biological membranes at the fastest rate. Once ingested, it functions as a signaling molecule and metabolic substrate. The principal signaling action involves the activation of the sympathetic function of the central and peripheral nervous systems, which results in increased sensitivity and normalized function of the hypothalamus.
Activation of the hypothalamus effectively regulates the entire endocrine system. In addition, succinates contribute to the stabilization of Hypoxia Inducible Factor (HIF), which accounts for improvement of the blood flow and the speeding-up of the synthesis of erythrocytes that, is responsible for transporting oxygen, and aids in the adaptation of the tissue to hypoxic conditions. In other words, the body better adjusts to oxygen deficiency induced by cardiovascular pathologies or during strenuous physical activities.
Ammonium Succinate is an energy-producing substrate, combined with ammonium ions, and it stabilizes mitochondrial activity in the cells. Mitochondria are the “energy stations” of each cell, especially active in the cells of the heart, liver and kidneys. An interesting point to note is that while succinates contribute to mitochondrion stimulation under the condition of energy and oxygen deficiency, they have an opposite effect in the event of mitochondrial hyperactivity. Mitochondrial hyperactivity provokes the production of active forms of oxygen and nitrogen, also known as free radicals.
In this case, Ammonium Succinate slows down mitochondrial activity and suppresses the generation of free radicals at the mitochondrial level, acting like a specific, water-soluble antioxidant. Therefore, succinates in the body possess energy-regulating, hypoxia-preventing and adaptogenic properties on both the regulatory and metabolic level, which can help the body cope with physical or psycho-emotional stress.
Calcium Disuccinate is the source of easily absorbed calcium, which is vital for regulating myocardial contractility and slowing down bone thinning.
Monosodium L-Glutamate is a salt of an amino acid, and functions as a neurotransmitter. It also helps memory loss.
We use a safe, small amount (40mg per each dose of Amberen) of pharmaceutical-grade bioactive Monosodium L-Glutamate, which is very different from the quality and quantity of MSG used in processed foods.
Studies show that Monosodium L-Glutamate isn’t likely to cause an allergic reaction, or any other adverse side effects, unless you use extremely high doses (1,000 – 10,000 times higher than recommended).
On the contrary, small dosages of Monosodium L-Glutamate, as used in Amberen, have been shown to positively affect the performance of mitochondrial-benzodiazepine receptors in peripheral tissues and stabilize energy status.
A more detailed explanation of Monosodium L-Glutamate is available on the FDA website:http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=217
Glycine is an amino acid, involved in the processes regulating brain cell activity.
In combination with magnesium, it lowers the sensitivity of glutamate receptors and makes brain mitochondrion more resistant to hypoxia, which, in turn, results in the normalization of the psycho-emotional balance in the body.
Magnesium Disuccinate Hydrate
Magnesium Disuccinate Hydrate is the source of easily absorbed magnesium, which is essential for a healthy cardiovascular system.
It is also vital for the effective engaging and regulation of ATP in all energy-dependent cell reactions. Furthermore, it performs the functions of regulation and inhibition of the central and peripheral glutamate receptors.
Zinc Difumarate Hydrate
Zinc Difumarate Hydrate is one of the sources of zinc and fumarate, which play an important role in energy metabolism.
Zinc ions are essential to the formation of ferments with active zinc centers, which are involved in important processes of hormone synthesis occurring in the body. Sufficient amounts of zinc enhance the metabolism of beta cells in the pancreatic islets of Langerhans and promote insulin synthesis and activity.
This in turn contributes to the normalization of fat and carbohydrate metabolism.
Vitamin E (in its form as Tocopherol Acetate) is a fat-soluble, natural antioxidant that prevents lipid peroxidation of cell membranes. Cell organelles and most importantly, the DNA contained in the nucleus, rely on the membrane to protect them.
Antioxidant properties of tocopherol, supplemented by water-soluble succinate anions, promote the stabilization of membrane structure, as well as general cell functions.