Clinical Trials

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It took decades to bring Amberen to market: decades of studies, rigorous testing for safety and efficacy, monitoring for long-term effects. Now, we can proudly say that Amberen is SAFE and EFFECTIVE.

First Amberen prototype tested

In 1971, for the first time, a team of researchers reversed menopause in aging rats by restoring their hypothalamic function. An early prototype of Amberen, as it would turn out.

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Studies on Amberen Formulation

Human Clinical Trials

2012, Los Angeles, CA – In a 12-week randomized, double blind, placebo controlled human clinical study, the subjects in the active group who were taking Amberen demonstrated both statistically and clinically significant reductions of many symptoms of menopause. On the Menopause Specific Quality of Life scale (MenQOL), the active group demonstrated statistically significant symptomatic relief in comparison with placebo group in the Pyschosocial subscale, which includes irritability and anxiety among other symptoms. No serious adverse side effects of Amberen were registered.

2001, Moscow, Russia- In a randomized, double blind, placebo controlled human clinical study Amberen based therapy lowered many characteristics of menopausal symptoms with statistical significance when compared with placebo group. Those symptoms include hot flashes, sleeplessness and muscle and joint pains among others. A clinically important alleviation of low libido, headaches and other symptoms was also observed. No serious adverse side effects of Amberen were registered. The results of this study have been published in several peer-reviewed publications:

(2008) A Succinate-Based Composition Reverses Menopausal Symptoms Without Sex Hormone Replacement Therapy. Advances in Gerontology, Vol. 21, No. 2, pp. 298-305.

(2007) A Succinate-Based Composition” Rejuvenates” Aging Mice and Alleviates Menopausal Symptoms in Women Without Sex Hormone Replacement Therapy. Medline (Gerontology, Endocrinology), Vol. 8, Art. 46, pp. 497-517.

(2005) Succinate-Based Preparation Alleviates Manifestations of the Climacteric Syndrome in Women. Bulletin of Experimental Biology and Medicine (Pharmacology and Toxicology), Vol. 140, No. 3, pp. 312-314.

2001 to 2004, Russia- In a 3-year long term, multi-center observational clinical study 245 women were treated with Amberen and observed by their physicians. Amberen was “found to be a highly effective monotherapy” for treatment of menopausal symptoms. No serious adverse side effects of Amberen were registered.

Amberen is also backed by a comprehensive toxicology dossier, including the studies of acute toxicity, genotoxicity (mutational effects), gravimetrical analysis of the femur tissue, elemental analysis of femoral bone tissue (Ca, Zn, K, Na, Mg), age-related changes to the estrous (ovulation) cycle, etc., that establish the product’s safety.

Studies on Active Ingredients

2006

Succinate as geroprotector in the course of chronological aging. V. A. Samokhvalov, M. N. Kondrashova. Biochimie.

2006

Signal, sympathetic action of succinate in experimental and clinical studies. E. I. Maevsky, A. S. Rosenfeld, A. B. Peskov, M. N. Kondrashova, BBA, Suppl.v.14, 14th EBEC Short Reports, 536-537.

2002

Hormone-like action of amber (succinic) acid. M. N. Kondrashova. Voprosy Biol. Med. Pharmac. Chemistry, Moscow 1, 7-12.

2000

Mechanisms of physiological activity and curative effect of small doses of succinic (amber) acid. M. N. Kondrashova, European Journal of Medicine, Res. 5, 28.

1991

Succinic acid as a physiological signal molecule. In: Signal Molecule and Behaviour. M. N. Kondrashova, S. P. Volkova, I. V. Kuznetzov, Manchester University Press, Manchester & New York, 295-300.

1982

Succinic acid as the only energy support of intensive Ca2+ – uptake by mitochondria. M. N. Kondrashova, V. G. Gogvadze, A. M. Babsky, Bioch. Bioph. Res. Comm. 109, 2, 376-381.

1976

The effect of amber (succinic) system in old rats. V. M. Dilman et al. Pharmacology and Toxicology, Moscow, 3, 540.

1976

Therapeutic action of amber (succinic) acid (M. N. Kondrashova), ONTI Pushchino.

1972

Accumulation and utilization of amber (succinic acid) in mitochondria. M. N. Kondrashova, Nauka, Moscow, 151-169.

Try Amberen Today for Menopause Relief

If you’ve been suffering from menopause symptoms without relief in sight, we invite you to try Amberen risk-free. Step away from the stress and discomfort of menopause symptoms — and into a new phase of rejuvenated health and well-being with Amberen.

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PLEASE NOTE: If you’re currently taking any prescription or over-the-counter medications that are designed to alter your natural hormone levels, Amberen may not be right for you. Make sure to consult your doctor, especially if you are a cancer survivor or have a severe thyroid disorder.